Radiological protection and assessment of genetic risk.
نویسنده
چکیده
Over the past decade there has been steadily increasin pressure from interested groups of people to quantif the genetic and somatic risks of ionising radiation The assessment of genetic risk is usually made fron data obtained fromcontrolledexperiments onanimals especially mice, often using the concept of th 'doubling dose'. This is the radiation dose whic] doubles the natural mutation frequency. This value i then applied directly to data on the frequencies o various hereditary diseases in man. The assumptioi that doubling doses determined for mice can b applied across the whole range of human geneti disease is not firm and requires further validation However, the use ofa single doubling dose for severa mutational endpoints does have support as shown i the Figure and the Table. A value of 30 rad might b appropriate for acute exposures and 100 rad fo chronic irradiation. To use the doubling dose concept we need t4 achieve a clear-cut division of the whole gamut o human hereditary disease into a small number o operationallydistinct categories. Wherechromosoma changes are concerned it is necessary to distinguisl between aneuploidies and structural changes, whil4 for gene mutations and small deficiencies it is no only necessary to distinguish between deleteriou dominant and sex-linked conditions and recessives but also to consider separately those conditions whici
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عنوان ژورنال:
- Journal of medical genetics
دوره 14 5 شماره
صفحات -
تاریخ انتشار 1977